POP患者盆底组织中MMP-3、TIMP-3的研究

Study on MMP-3 and TIMP-3 in paries anterior vaginase for female pelvic floor prolapse

目的:探讨盆腔器官脱垂(Pelvic floor prolapse,POP)患者阴道壁粘膜组织中基质金属蛋白酶-3(Matrix metalloproteinase-3,MMP-3)、组织金属蛋白酶抑制物-3(Tissue inhibitor of metalloproteinase-3,TIMP-3)表达,分析其与疾病发生的关系。方法:采用免疫组化方法,测定30例盆腔器官脱垂(POP)患者(POP组)阴道壁粘膜组织中MMP-3及TIMP-3阳性表达率,并选择同期20例非卵巢功能性肿瘤和宫颈病变患者作为对照(对照组)。结果:POP患者阴道壁粘膜组织中MMP-3表达显著高于对照组(P<0.05),TIMP-3表达显著低于对照组(P<0.05)。结论:POP患者盆底支持结构的退行性病变与阴道壁粘膜组织中胶原代谢活跃、胶原的分解增加有关。

Objective： To explore the relationship between matrix metalloproteinase （MMP） -3 and tissue inhibitor of metallo- proteinase （TIMP） -3 in paries anterior vaglnase with the occurrence of pelvic floor prolapse. Methods： The biopsy specimens in paries anterior vaginase were obtained from 50 subjects undergoing hysterectomia, who were assigned into control, pelvic organ prolapse （PO P） . MMP -3 and TIMP -3 in structures in paries anterior vaglnase was evaluated by immunohistochemical staining. Results： MMP -3 positive staining rate of paries anterior vaginase in POP group was significantly higher than that in control group （ P 〈 0. 05 ）, TIMP - 3 positive staining rate of paries anterior vaginase in POP group was significantly lower than that in control group （ P 〈 0.05 ） . Conclusion. There is close relationship between degeneration of pelvic support construction and deficiency in MMP - 3 activated and TIMP - 3 declined in paries anterior vaginase of POP patients.