一种潜在的肿瘤治疗剂- ^(186)Re(V)-DMSA 的初步研究

PRELIMINARY STUDY ON A POSSIBLE TUMOR RADIOTHERAPY AGENT—— 186 Re(V) DMSA

１８６Ｒｅ（Ｖ）－ＤＭＳＡ是由ＳｎＣｌ２在ＤＭＳＡ和Ｖｃ存在的条件下，１００℃加热３０ｍｉｎ，还原Ｈ１８６ＲｅＯ４所得。标记物经ＨＰＬＣ分析表明为单一的化合物，即１８６Ｒｅ（Ｖ）－ＤＭＳＡ。１８６Ｒｅ（Ｖ）－ＤＭＳＡ在生理盐水中可稳定２４ｈ，在人血清蛋白中可稳定１８ｈ，在昆明小白鼠体内的生物分布与９９Ｔｃｍ（Ｖ）－ＤＭＳＡ相似，在骨中浓聚最高，其次是肾。

Re(V) DMSA,an analogue of the tumor imaging radiopharmaceutical 99 Tc m(V) DMSA,has possible value in tumor therapy. It is readily prepared by stannous reduction of H 186 ReO 4 in the presence of dimercaptosuccinic acid ( meso DMSA) at 100 ℃ for 30 min. The labeling compound is identified as 186 Re(V) DMSA by HPLC. The 186 Re(V) DMSA is decomposed 5% after 24 h and 18 h in physiological saline and human serum respectively. The biodistribution of 186 Re(V) DMSA and 99 Tc(V) DMSA in normal Kunming mice is similar,the highest accumulation in bone and higher in kidney.