不同硒水平地区儿童红血球、大米和土壤中的铷含量测定

Rubidium contents in erythrocyte of children, rice and soil in the areas with different selenium status

用ＰＩＸＥ方法测定了四川省四个不同硒水平的克山病区和非克山病区的６－１１岁健康儿童红血球中铷（Ｒｂ）含量，发现克山病区儿童红血球中Ｒｂ含量高于其它三个地区。同时用辅酶Ⅱ（ＮＡＤＰＨ）偶联法测定含硒酶谷胱甘肽过氧化酶（ＧＳＨＰｘ）的活力，证明克山病区儿童确处于低硒状态。两年后，又用中子活化法测定了克山病区和补硒控制发病的老病区的大米和土壤中的Ｒｂ含量，发现克山病区的大米和土壤中Ｒｂ含量也显著高于补硒地区，说明克山病区儿童红血球中Ｒｂ含量高是由于摄入Ｒｂ水平高所致。

Rubidium concentration of erythrocyte of healthy children aged from 6-11 years living in four areas of Sichuan Province with different selenium status was measured by PIXE and the results show that the Rb concentration in erythrocyte for the Keshan Disease area is two times more than other three areas Meanwhile the glutathione peroxidase (GSHPx) activity of erythrocyte was determined and the results confirm that children in the Keshan Disease area are really with selenium deficiency The Rb contents in rice and soil samples from the Keshan Disease area and the Se-deficiency area but with Se-supplementation to the inhabitants, were tested by INAA It was found that Rb contents in rice and soil from the former area were much higher than those from the latter This result indicates that Rb in erythrocyte of children is mainly taken from staple food (rice) and that a higher Rb level in soil is probably another environmental factor causing the Keshan Disease