神经电生理定量测定偏头痛患者自主神经功能及其意义初探

Autonomic function in patients with migraine: a quantitative study by neuroelectrophysiology

目的探讨自主神经系统在偏头痛伤害性信息传递中的作用。方法应用神经电生理测定了56例偏头痛患者和30例健康人交感神经皮肤反应。结果偏头痛患者发作期、间歇期交感神经皮肤反应的潜伏期均明显长于正常对照组,而波幅显著低于对照组;偏头痛发作期的潜伏期显著长于间歇期,波幅显著低于间歇期。结论偏头痛患者存在交感神经功能低下。

[Objective] To explore the involvement of autonomic nervous system in the transmission of nociceptiv information related to migraine. [Methods] Using neuroelectrophysiology, sympathetic skin response（SSR） was recorded in a group of 56 patients with migraine and in a control group of 30 healthy volunteers. [Results] Compared with the control group, the latency of SSR was significantly prolonged, the wave amplitude decreased in patients with migraine. The latency was notably longer, the wave amplitude decreased in the attack period of migraine than that of intermittent. [Conclusion] This suggested an impairment of the sympathetic function in patients with migraine.