期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

HCN通道在神经系统中的功能和作用 被引量：3

下载PDF
导出
摘要 HCN通道(hyperpolarization-activated cyclic nucleotide-gated channels)是一种超极化激活的,选择性通透K+、Na+,直接受cAMP调控的离子通道,其在神经系统中有多方面的功能并与癫痫等神经疾病有关系。对HCN通道正常生理功能以及与疾病的关系的深入认识,必将对今后的研究和临床有深远的意义。
作者 岳鑫 王均辉 秦绿叶 于常海
机构地区 北京大学神经科学研究所；北京大学医学部神经生物学系；教育部神经科学重点实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2008年第3期247-250,共4页 Progress in Physiological Sciences
基金 国家自然科学基金(30270426,30470543) 北京市自然科学基金(7032026,7051004)资助课题
关键词 HCN通道 超极化激活 神经系统
分类号 Q42 [生物学—神经生物学]
  • 相关文献

参考文献9

  • 1Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol, 2003, 65:453-480.
  • 2Van W, I, Van Hooft JA, Wadman WJ. Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization-activated Th channels. Proc Natl Acad Sci, 2004, 101:5123-5128.
  • 3Ying S-W, Jia F, Abbas SY, et al. Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons. J Neurosci, 2007, 27 : 8719 -8732.
  • 4Whitaker GM, Angoli D, Nazzari H, et al. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. J Biol Chem, 2007, 282 : 22900 - 22909.
  • 5Zolles G, Klocker N, Wenzel D, et al. Pacemaking by HCN channels requires interaction with phosphoinositides. Neuron, 2006, 52 : 1027- 1036.
  • 6Chen C. ZD7288 inhibits postsynaptic glutamate receptor- mediated responses at hippocampal perforant path-granule cell synapses. Eur J Neurosci, 2004 19 : 643 -649.
  • 7Jung S, Jones TD, Lugo JN, et al. Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy. J Neurosci, 2007, 27 : 13012- 13021.
  • 8Brewster A, Bender RA, Chen Y, et al. Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform-and cell- specific manner. J Neurosci, 2002, 22 : 4591 -4599.
  • 9Wang M, Ramos BP, Paspalas CD, et al. Alpha2a-adrenoceptors strengthen working memory networks by inhibiting camp-HCN channel signaling in prefrontal cortex. Cell, 2007, 129 : 397-410.

同被引文献28

  • 1涂会引,万有.超极化激活环核苷酸门控的超极化阳离子通道在神经系统中的分布与功能[J].神经损伤与功能重建,2006,1(1):45-48. 被引量：1
  • 2Nazzari H, Angoli D, Chow SS, et al. Regulation of cell surface expres- sion of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domain [ J ]. Physiol Cell Physiol, 2008, 295 : C642 - C652.
  • 3Del Lunqo M, Melchiorre M, Guandalini L, et al. Novel blockers of hy- perpolarization-activated current with isoform selectivity in recombi- nant cells and native tissue[ J ]. Br J Pharmacol,2012,166 (2) :602 -616.
  • 4Biel M, Wahl-Schott C, Michalakis S, et al. Hyperpolarization-activa- ted cation channels : from genes to function [ J ]. Physiol Rev, 2009, 89:847 - 885.
  • 5Chaplan SR, Guo HQ, Lee DH, et al. Neuronal hyperpolarization-acti- vated pacemaker channels drive neuropathic pain [ J ]. Neurosci, 2003,23:1169 - 1178.
  • 6Nolan MF, Dudman JT, Dodson PD, et al. HCN1 channels control rest- ing and active integrative properties of stellate cells from layer II of the entorhinal cortex [ J ]. Neurosci ,2007,27 (46) : 12440 - 12451.
  • 7Hussaini SA, Kempadoo KA, Thuault S J, et al. Increased S ize and Stability o f CA1 and CA3 Place Fields in HCN1 Knockout Mice[ J]. Neuron ,2011,72 (4) :643 - 653.
  • 8Tsay D, Dudman JT,Siegelbaum SA. HCN1 channels constrain synap- tically evoked Ca2 spikes in distal dendrites of CA1 pyramidal neu- rons[ J ]. Neuron ,2007,56 : 1076 - 1089.
  • 9Tokay T,Rohde M, Krabbe S, et al. HCN1 channels constrain DH- PG-induced LTD at hippocampal Schaffer collateral-CA1 synapses [ J ]. Learn Memory ,2009,16 ( 12 ) :769 - 776.
  • 10Nolan MF, Malleret G, Lee KH, et al. The hyperpolarization-activatedHCN1 channel is important for motor learning and neuronal integra- tion by cerebellar Purkinje cells [ J]. Cell,2003,115:51 - 564.

引证文献3

二级引证文献16

生理科学进展
2008年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部