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信号转导通路与表观遗传模式在学习和记忆中的作用

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摘要 海马区神经突触长时程增强(LTP)是应用最广的神经突触可塑性研究模型,为学习和记忆脑功能的基础。cAMP反应元件结合蛋白(cAMP-CREB)、Ras/细胞外信号调节激酶(Ras/ERK)等信号通路参与了学习和记忆的过程。通过组蛋白乙酰化和DNA甲基化对染色质结构进行调节,可以介导长时间、持续性的学习和记忆行为变化,其中,丝裂素活化蛋白激酶(MAPK)级联通路起到了关键作用。本文就学习和记忆形成中的信号转导、表观遗传模式及两者在学习和记忆中的作用进行综述。
作者 刘喜娟 黄辰 杨章民 宋土生 黄汾生
机构地区 陕西师范大学生命科学学院 西安交通大学医学院遗传学与分子生物学系/环境与疾病相关基因教育部重点实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2008年第3期264-267,共4页 Progress in Physiological Sciences
关键词 信号转导 表观遗传学 学习 记忆
分类号 Q75 [生物学—分子生物学]
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参考文献9

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二级参考文献22

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生理科学进展
2008年 第3期

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