应用光学相干断层扫描仪对视乳头水肿患者的临床研究

Detection of retinal nerve fiber layer thickness in optic disc edema using stratus OCT

目的应用光学相干断层扫描(optical coherence tomography,OCT)观察视乳头水肿患者的视网膜神经纤维层厚度与形态的改变。方法采用OCT追踪测量30例有视乳头水肿的患者其在首诊,第1周,第1个月,第2个月,第3个月视盘周围视网膜神经纤维层厚度。动态观察视网膜神经纤维层厚度的改变,OCT图像特征和变化。结果视乳头水肿患者的视盘周围视网膜神经纤维层厚度呈先增厚再萎缩变薄的过程,并发现在水肿的神经纤维层下存在一个低反射区。结论OCT能定性、定量动态地观察到视乳头水肿的病情演变。

Objective To investigate the ability of optical coherence tomography（OCT） to assess changes in retinal nerve fiber layer （RNFL） thickness in optic disc edema.Methods 34 consecutive eyes （30 patients） with optic disc edema were analyzed, Peripapillary scans of the RNFL were obtained using Stratus OCT.Repeated measurements were performed in 30 patients during a follow-up ranging from the first day to the third months.The main outcome was RNFL thickness measurement.Results Optical coherence tomography detected and quantified diffuse thickening of the RNFL. Eyes with optic disc edema showed a significant increase in the mean RNFL thickness ,when followed up,progressive thinning was observed as the disease evolved toward optic atrophy or clinical resolution.Conclusion Optical coherence tomography can identify and measure RNFL edema. This ability of OCT may provide a valuable aid to clinicians.