西藏地区^(14)C尿素呼气试验检测幽门螺杆菌7年情况分析

目的探讨7年间幽门螺杆菌(Hp)感染变化及其与常见上消化道良性疾病、年龄的关系。方法分析2001年1月~2007年12月均接受尿素呼气试验(14C-UBT)检查和胃镜检查的所有病例,共计15644例。观察Hp感染与年代、常见上消化道良性疾病—消化性溃疡(PU),慢性浅表性胃炎(CSG),慢性萎缩性胃炎(CAG),反流性食管炎(RE)以及年龄的关系。结果7年来Hp的平均检出率为60%,2002和2007年检出率最高,均为63%,而2004年检出率最低,为52%。常见上消化道良性疾病当中PU、CSG、CAG、RE的Hp检出率分别为,70%、59%、55%和42%。各年龄段中,<10、11~19、20~29、30~39、40~49、50~59和>60岁的Hp检出率分别为,52%、60%、64%、56%、55%、41%和40%。结论7年间Hp检出率出现双高峰,第一高峰出现于2002年,而第二高峰出现于2007年,2001年到2004年期间呈下降趋势;常见上消化道良性疾病当中,PU患者Hp检出率最高,RE检出率最低,而CSG、CAG患者居中。从年龄结构,青少年Hp检出率最高,而老年人相对较低,中年人和儿童居中。

Objective To study the changes of Hp infection status and the relationship between Hp infection and common diseases of upper digestive tract and age according to the clinical data of ^14C-UBT and endoscopy in our hospital during the past 7years. Methods 15 644 patients had been diagnosed by both ^14C-UBT and endoscopy from Jan. 2001 to Nov. 2007 were investigated. The relationship between Hp infection and major diseases of upper digestive tract and age were studied. Results The average detection rate of Hp is 60%. The detection rate of Hp in 2002 and 2007 was 63 % and 63 % respectively, which was highest detection rate. The lowest detection rate was in 2004, which was 52%. The detection rate of Hp of PU, CSG, CAG and ER was 70% ,60% ,55 % and 42% respectively. The detection rate of Hp at least 10 years,11 to 19years,20 to 29 years,30 to 39 years,40 to 49 years,50 to 59 years and over 60 years was 52% ,60% ,64% ,56% ,55% ,41% and 40% respectively. Conclusion The detection rate of Hp shows two peaks in the past 7 years, and there are dec 1 ine intense of it from 2002 to 2004. Among the common diseases of upper digestive tract, the detection rate of Hp of PU is highest, and ER is the lowest one. In concerned of age, the highest detection rate of Hp be found among 11 to 29 years, and the lowest in over 60 years patients.