东莞地区50387例高考学生HBsAg检测结果分析

Analysis of HBsAg Detection Results among 50387 College Candidates in Dongguan Area

目的了解东莞地区中学生乙型肝炎病毒(hepatitis B virus,HBV)的感染现状,为HBV感染的防治提供依据。方法采用酶联免疫吸附试验方法(ELISA法)分别检测2001-2007年高考体检学生共50 387人的HBsAg,对检测结果统计分析,比较不同性别和城乡间的HBsAg感染的差异。结果2001-2007年高考学生HBsAg的携带率分别为23.69%、18.58%、16.22%、14.88%、10.98%、6.68%、4.04%,呈逐年下降趋势(P<0.01);乡镇学生HBsAg平均阳性率为12.65%,显著高于城镇学生的平均阳性率8.75%(P<0.01);男性的HBsAg阳性率为12.86%,显著高于女性的阳性率9.2%(P<0.01)。结论被调查的东莞市2001-2007年高考学生的HBV感染率(平均感染率11.14%)高于全国的HBV平均感染率(10%),HBsAg的携带率呈逐年下降趋势;乡镇学生HBV感染率明显高于城镇学生,男生高于女生。

Objective To investigate the HBsAg carrier rate of the college candidates in towns and villages from 2001 to 2007, find out the current HBV infection situation among middle school students in Dongguan, and provide a scientific basis for prevention and treatment of HBV infection. Method Enzyme-Linked ImmunoSorbent Assay （ELISA） was performed to detect HBsAg among 50387 college candidates from 2001 to 2007. Statistical analysis was performed to compare the HBV infection in different gender and area. Result The carrier rates of the college candidates from 2001 to 2007 decreased year by year （P〈0.01）, with the rates of 23.69%, 18.58%, 16.22%, 14.88%, 10.98%, 6.68%, 4.04%, respectively. The average HBsAg infection rate of village students was 12.65%, significantly higher than that of town students which was 8.75%（P〈0.01）. The infection rate of male was 12.86%, much higher than that of female which was 9.2%（P〈0.01）. Conclusion The average HBV infection rate of the college candidates in Donggnan from 2001 to 2007 was 11.14%, significant higher than that of average level in China （10.0%）. The HBsAg carrier rate decreased year by year. The HBV infection rate of village students was higher than that of town students, and the rate of male was higher than that of female.