中药大黄素治疗中重度牙周炎的临床观察

Clinical Observation of Emodin on the Treatment of Moderate to Severe Periodontitis.

目的:评价中药大黄素局部治疗牙周炎的临床疗效。方法:将36例中、重度慢性牙周炎患者,随机分为龈下刮治组(对照组)和大黄素+龈下刮治组(实验组)。记录两组治疗前后的临床牙周指数、龈沟液量及龈沟液IL-1β浓度。结果:两组治疗后临床牙周指数、龈沟液量和龈沟液IL-1β浓度与治疗前相比均有显著性差异(P<0.05,P<0.01);实验组治疗后龈沟液IL-1β浓度明显降低,其抑制率为74.82%优于对照组。结论:中药大黄素临床治疗牙周炎可行。

Objective： To evaluate the therapeutic effect of Chinese traditional medicine emodin on periodontitis. Methods： 36 patients with moderate to severe periondotitis were recruited and randomly divided into two groups. Patients in one group were treated with only subgingival scaling （Control group）, patients in the other group were treated with emodin plus subgingival scaling （Experimental group）. Results： Clinical periodontal index, amount of gingival crevicular fluid and concentration of IL-1β in gingival crevicular fluid were all significantly improved in both groups （P〈0.05, P〈0.01）. But the concentration of IL-1β in Experimental group were obviously lower than Control group. The inhibit ratio was 74. 82% , Conclusion： It is applicable to use Chinese traditional medicine emodin in the treatment of periodontitis.