新生儿支原体感染情况的初步观察

A preliminary observation of mycoplasma infection in neonates

为了探讨致病性支原体对新生儿的影响，采用间接血细胞凝集方法检测了３２３例住院新生儿血清中支原体特异抗体。结果：３２３例中５６例阳性，阳性率１７．３％。其中解脲脲原体２６例，阳性率４６．４％，人型支原体１６例，占２８．６％，二者合计４２例，占７５．０％。３３例做了双份血清抗体检测，１７例抗体阳性，并且两次间抗体滴度有变化，其中９例阳性转为阴性，７例阴性转为阳性，１例滴度继续升高。检测了１９例早产儿，阳性６例，阳性率３１．６％。所有支原体抗体阳性新生儿未见特异症状和体征，与原病种无明显关系。提示：新生儿对支原体的感染，以解脲脲原体和人型支原体为主，早产儿感染率相对较高。由于感染和检测时间的早晚，一次抗体阴性不能除外支原体感染。

To examine the impacts of Mycoplasma (MP) on neonates, the authors detected the serum specific antibody to mycoplasma in 323 hospitalized neonates. Fifty six cases (17.3%) were positive, 26 of whom were positive for Ureaplasma urealyticum (Uu), accounting for 46.4% of the positive cases and 16 for Mycoplasma hominis (Mh), accounting for 28.6% of the positive cases. Taken together Uu and Mh, 42 neonates (75.0% of all positive cases) were revealed positive. The double serum specimens were tested in 33 neonates. Seventeen of them were positive and the titer changed between the double sera, in 9 of which it changed from positive to negative, in 7 from negative to positive, and continuously went high in 1. Nineteen preterm infants were tested and 6 preterm infants (31.6%) were positive. These results indicated that there was a high infection rate of Uu and Mh in neonates, in whom no specific clinical manifestation was observed. Mycoplasma infection cannot be excluded based on only one negative result of antibody detection.