Nd-YAG激光汽化结合光动力学治疗对鼻咽癌患者SIL-2R、IL-2水平及NK活性的影响

EFFECT OF YAG LASER VAPORIZATION AND PHOTODYNAMIC THERAPY ON SERUM LEVELS OF SIL-2R AND IL-2 AS WELL AS ON NK ACTIVITY OF PATIENTS WITH NASOPHARYNGEAL CARCINOMA

应用双抗体夹心ＥＬＩＳＡ法、３Ｈ－ＴｄＲ掺入法和１２５Ｉ－ＵｄＲ释放法对２４例鼻咽癌（ＮＰＣ）患者ＹＡＧ激光汽化结合光动力学治疗前后外周血可溶性ＩＬ－２受体（ＳＩＬ－２Ｒ）、白细胞介素２（ＩＬ－２）水平和自然杀伤细胞（ＮＫ）活性分别进行测定。结果表明鼻咽癌患者在接受激光光动力学治疗后ＳＩＬ－２Ｒ水平呈明显下降（Ｐ＜０．０００５），而ＩＬ－２水平和ＮＫ活性显著上升（Ｐ＜０．０００５）。结果提示激光光动力学治疗对恢复鼻咽癌患者免疫功能起促进作用。

Serum levels, both before and after laser vaporization combination with photodynamic therapy (PDT), of soluble interleukin-2 receptor (SIL-2R) and interleukin-2 (IL-2) as well as activity of natural killers (NK) were determined among 24 patients with either persistent or recurrent nasopharyngeal carcinomas (NPC) using double antibody sandwich technique, 3H-TdR incorporation and 125 I-UdR release techniques respectively. The results showed that the post-PDT serum level of SIL-2R was significantly declined ( P <0.0005) while that of IL-2 and the activity of NK were significantly increased ( P <0.0005) as compared with those of pre-PDT, suggesting an immuno enhancing effect of the laser vaporization combination with PDT on NPC patients.