放射治疗结合EGFR靶向抑制剂治疗非小细胞肺癌研究进展
被引量:1
摘要
肺癌是全球导致癌症死亡的最主要原因。约80%的肺癌是非小细胞肺癌(non—small—cell lung cancer,NSCLC)。对于Ⅰ、Ⅱ期及部分选择性的Ⅲ期患者,手术切除是首选的治疗方法,遗憾的是临床上仅25~30%的NSCLC可选择根治性手术。对于不能手术切除的NSCLC,单纯放射治疗或放化疗综合治疗提供了唯一的治愈机会,但总的治疗疗效并不理想,5年生存率仅5~10%,
出处
《中国肺癌杂志》
CAS
2008年第1期147-150,共4页
Chinese Journal of Lung Cancer
参考文献32
-
1Baumann M,Stamatis G,Thomas M.Therapy of localized non-small cell lung cancer(take home messages).Lung Cancer,2001,33(Suppl 1):4749.
-
2Barker FG 2nd,Simmons ML,Chang SM,et al.EGFR overexpression and radiation response in glioblastoma multiforme.Int J Radiat Oncol Biol Phys,2001,51(2):410-418.
-
3Akimoto T,Hunter NR,Buchmiller L,et al.Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas.Clin Cancer Res,1999,5(10):2884-2890.
-
4Hendler FJ,Ozanne BW.Human squamous cell lung cancers express increased epidermal growth factor receptom.J Clin Invest,1984,74(2):647-651.
-
5Nyati MK,Morgan MA,Feng FY,et al.Integration of EGFR inhibitors with radiochemotherapy.Nat Rev Cacer,2006,6(11):876-885.
-
6Thomas SM.Grandis JR.Pharmacokinetic and Pharmacodynamic properties of EGFR inhibitors under clinical investigation.Cancer Treat Rev,2004,30(3):255-268.
-
7Akimoto T,Hunter NR,Buchmiller L,et al.Inverse relationship between epidermal growth factor receptor expression and radiocurabihty of murine carcinomas.Clin Cancer Res,1999,(10):2884-2890.
-
8Ang KK,Berkey BA,Tu X,et al.Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.Cancer Res,2002,62(24):7350-7356.
-
9Petersen C,Eicheler W,Frommel A,et al.Proliferation and micromilieu during fractionated irradiation of human FaDu squamous cell carcinoma in nude mice.Int J Radiat Biol,2003,79(7):469-477.
-
10Eriksen JG,Steiniche T,Askaa J,et al.The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck.Int J Radiat Oncol Biol Phys,2004,58(2):561-566.
同被引文献5
-
1杨学宁,吴一龙.实体瘤治疗疗效评价标准——RECIST[J].循证医学,2004,4(2):85-90. 被引量:1565
-
2徐晓颖,王若雨,乔京京.放射治疗肺癌脑转移的预后因素分析[J].肿瘤学杂志,2005,11(6):435-437. 被引量:5
-
3朱岩,张晓彤,李龙芸.EGFR酪氨酸激酶域基因变异及相关蛋白表达与gefitinib治疗晚期非小细胞肺癌疗效相关性的研究进展[J].癌症进展,2006,4(2):147-151. 被引量:7
-
4王燕,王颖,王彬,王子平,张湘茹,储大同,孙燕.吉非替尼治疗非小细胞肺癌脑转移的初步结果[J].中国肺癌杂志,2006,9(5):447-451. 被引量:33
-
5Wronski M,Arbit E,Burr M,et al.Survial after surgical treatment of brain metastases from lung cancer:a follow-up study of 231 patients treated between 1976 and 1991[J].J Neurosurg,1995,83(4):605 -616.
二级引证文献4
-
1张小红,李书容,尚友兰,张海霞,黄磊.放疗固定安全带的制作与临床应用[J].海南医学,2013,24(3):422-423.
-
2郝艳坤,杜宇,王涓.厄洛替尼辅助全脑放疗治疗肺癌脑转移疗效分析[J].医学综述,2014,20(14):2660-2661. 被引量:3
-
3秦琛,田莹莹,赵清叶,王文明.厄洛替尼联合放疗治疗非小细胞肺癌脑转移的临床疗效观察[J].中国继续医学教育,2015,7(20):164-165. 被引量:7
-
4万欣,王军,曹峰,王祎,吴凤鹏,张萍,刘青,景绍武,杨从容,程云杰.厄洛替尼加减脑部放疗治疗非小细胞肺癌脑转移临床观察[J].中国医师杂志,2016,18(5):653-658. 被引量:9
-
1冯芬,李宇红,安欣,王风华,徐瑞华,潘志忠,何友兼,万德森.结直肠癌肺转移患者手术切除肺转移灶的疗效及预后分析[J].中华胃肠外科杂志,2009,12(5):471-473. 被引量:5
-
2赵鹏军,许亚萍,马胜林.阿米福汀在非小细胞肺癌放化疗中的应用及研究进展[J].中华放射医学与防护杂志,2009,29(4):452-455. 被引量:3
-
3王秀云,杨振亚.支气管、肺动脉成形术治疗肺癌的护理[J].护理研究(下旬版),2006,20(5):1361-1363. 被引量:6
-
4胡世新,尹兴儒,李明武.气管成型术治疗Ⅲ期非小细胞肺癌的疗效分析[J].中国医药指南,2013,11(5):83-84.
-
5牟巨伟,李鉴,程贵余,孙克林,赫捷.双侧同时双原发肺癌的一期手术治疗[J].中国医刊,2008,43(2):35-36. 被引量:2
-
6孙广伟,王本锋.内镜手术治疗甲状腺癌应用进展[J].西部医学,2013,25(1):156-157. 被引量:9
-
7关韶峰,潘欣,崔克俭,张卫,吴卫华,方唯一.50岁以上继发孔型房间隔缺损患者介入治疗和外科手术的对比分析[J].中国介入心脏病学杂志,2005,13(6):357-360. 被引量:3