肿瘤坏死因子β水平与多发性硬化临床表现的相关性

Association between the level of tumor necrosis factor β and the clinical features of multiple sclerosis

目的探讨肿瘤坏死因子（TNF）β水平与多发性硬化（MS）临床表现的相关性。方法应用双抗体夹心酶联免疫法测定58例MS患者（MS组）血清TNFβ水平;并与患者不同亚型、病期、神经功能缺损程度的扩展病残状态评分（EDSS）、病程、发病次数、发病年龄等临床情况进行相关性分析。结果（1）MS组急性期TNFβ水平较缓解期和正常对照组显著升高（P〈0.05-0.01）;MS缓解期与正常对照组间差异无统计学意义。（2）MS西方型急性期TNFβ水平较缓解期显著升高（P〈0.01）;MS亚洲型急性期与缓解期差异无统计学意义。（3）两亚型急性期、缓解期TNFβ水平与其EDSS、病程、发病次数及发病年龄均无相关性。结论（1）TNFβ水平与MS急性期存在相关,MS西方型急性期、缓解期变化更显著。（2）TNFβ水平与EDSS、病程、发病次数及发病年龄可能不相关。

Objective To investigate the relationship between the level of tumor necrosis factor （TNF） β and the clinical features of multiple sclerosis （ MS ）. Methods The TNFβ level of 58 MS patients （ MS group ） was determined by means of sandwich enzyme-linked immunosorbent assay （ELISA）. The correlative analysis between level of TNFβ and the Expanded Disability Status Scale （ EDSS ）, the clinical data （ including the duration of disease,the number of relapses and the age of onset） were take in MS patients. Results （ 1 ） TNFβ level was significantly increased in MS acute stage compared with those in MS remission stage and healthy controls （P 〈 0.05 - 0.01 ）, but there was no significant different between MS remission stage and healthy controls. （2）The TNFβ level of acute stage was significantly higher than that of remission stage in MS Western-type（ P 〈 0.05 ） , but not in MS Asian-type. （3）There was no significant positive correlation of TNFβ level of MS acute or remission stage in both sub-types to EDSS, the duration of disease, the number of relapses and the age of onset. Conclusions （ 1 ） There is significant association between the level of TNFβ and MS acute stage, especially in MS Western-type. （2）There is no positive correlation of TNFβ levels to EDSS, the duration of disease, the number of relapses and the age of onset.