加巴喷丁添加治疗难治性癫癎局灶性发作的疗效以及对记忆功能的影响

Curative effect and influence on memory function of Gabapentin as add-on therapy for treatment of focal seizures in refractory epilepsy

目的探讨加巴喷丁(GBP)添加治疗对难治性癫癎局灶性发作的疗效以及对记忆功能的影响。方法96例难治性局灶性发作癫癎患者随机分为两组,在原用药物基础上,GBP组给予GBP添加治疗,托吡酯(TPM)组给予TPM添加治疗;添加治疗前后应用临床记忆量表(CMS)对入组者进行记忆功能评估及疗效评估。结果添加治疗20周GBP组总有效率(75.0%)与TPM组(72.9%)相比差异无统计学意义;与添加治疗前比较,添加治疗后GBP组CMS评分差异无统计学意义;TPM组无意义图形再认、自由图像回忆、人像特点回忆和记忆商显著下降(均P<0.05)。结论GBP作为添加药物治疗难治性癫癎局灶性发作有效,对患者记忆功能无明显不良影响。

Objective To study the curative effect and influence on memory function of Gabapentin （GBP） as add-on therapy for treatment of focal seizures in refractory epilepsy. Methods 96 patients with focal seizures in refractory epilepsy were randomly divided into groups GBP and Topiramate （TPM）. Beside the normal medicaments, GBP or TPM as add-on therapy for certain group. According to the Clinical Memory Scale （CMS） , the patient＇s memory function was evaluated before and after treatment. Results There was no significantly difference of total effective rate between groups GBP （75.0%） and TPM （72.9%）. The scores of CMS showed almost same between before or after add-on therapy in GBP group. In TPM group, the scores of meaningless image recognition, free recall, phase portrait characteristics and memory quotient were significantly reduced after add TPM （ all P 〈 0. 05 ）. Conclusions GBP as add-on therapy for treatment of focal seizures in refractory epilepsy is effective and safety, and it is no visible negative influence on memory function.