代血浆置换在预防移植肾排斥反应的临床应用研究

Clinical Application of Exchanges with Plasma Substitutes in Preventing the Rejection of Renal Transplantation

作者对34例尿毒症患者在肾移植术前进行代血浆置换59例次以预防移植肾急性排斥反应,结果肾移植术后3月内急性排斥反应发生率为17.6％,明显低于常规肾移植组31.9％。采用不含抗原和抗体的代血浆作置换液,既能有效地置换出患者血浆中可能诱发移植肾排斥反应的抗体及其它免疫活性物质,又可避免由于使用人体新鲜血浆造成这些免疫物质的重新输入,从而达到预防移植肾排斥反应的目的。

In this paper.the results of exchanges with plasma substitutes in 59 instances of 34 cases with uremia after renal transplantation to prevent the acute rejection reactions were reported. It was found that the incidence of acute rejection reac-tiaos-within 3 months after renal transplantation was 17.6% and that of the control group was 31.9%.indicating a lower incidence of acute rejection reactions in the former group. By using the plasma substitutes that contain neither antigens nor antibodies, it is effective to exchange the antibodies that could induce the rejection reactions as well as other immune substances, and also avoid the reinfusion of these immune materials in the course of using fresh human plasma. It appears that the exchanges with plasma substitutes may play an important role in preventing the rejection reactions of renal transplantation.