氨己烯酸治疗难治性癫痫25例临床分析

Vigabatrin add on therapy in children with refractory epilepsy: an analysis of 25 cases

为探讨氨己烯酸对小儿难治性癫痫的治疗价值，采用增药试验的方法，观察了该药对２５例患儿的疗效及安全性。服药后２个月，总有效率６８．０％。服药≥４个月者共２４例，总有效率７０．８％（２１／２４）。服用氨己烯酸后，苯巴比妥血浓度低于用药前水平。血清丙氨酸转氨酶水平较服药前降低。２２例未见毒副作用；２例于服药后早期分别出现轻度头晕和困倦，均自行缓解；１例出现严重的躁动不安而终止治疗。观察结果表明，氨己烯酸对于小儿难治性癫痫有较好的疗效，患儿对其有较好的耐受性。

To assess the therapeutic effectiveness of vigabatrin in the treatment of refractory epilepsy in children, the authors observed its efficacy and safety in an open add on study on 25 cases. On two months′ therapy for 25 cases, the total effective rate was 68.0%. Among 24 patients with the administration of vigabatrin for 4 months or longer, the total effective rate was 70.8%. The blood level of phenobarbital decreased after the initiation of vigabatrin. Serum glutamic pyruvic transaminase level declined as compared with that prior to the vigabatrin therapy. No adverse effects were observed in 22 cases with a favorable tolerance. Two cases experienced mild dizziness and sleepiness on the early stage and they were relieved spontaneously. The treatment had to be discontinued in 1 case because of severe irritation. The results of the present study suggest that vigabatrin is effective and well tolerated in the treatment of refractory epilepsy in children.