咳嗽变异性哮喘患者主观评估和客观检测之间的相关性

Correlation of objective monitoring and subjective assessments in cough variant asthma

目的研究咳嗽变异性哮喘患者咳嗽生活质量问卷调查和1s用力呼出量／用力肺活量比值及峰流速变异率之间的相关性及其意义。方法选取52例咳嗽变异性哮喘患者作为研究对象，并按照哮喘严重程度分级的标准分为A组（CVAⅠ级组）、B组（CVAⅡ级组）、C组（CVAⅢ级组）、D组（CVA Ⅳ级组）四组；所有研究对象首诊时和规范治疗3月后均完成咳嗽生活质量问卷（CQLQ）调查，同时进行1s用力呼出量／用力肺活量比值（FEV1％）测定和峰流速变异率（PEFR）监测。结果（1）规范治疗前，A、B、C、D四组各组间FEV。％与PEFR均差异有显著性（P〈0．05），且两者具有明显负相关性（r=-0．995，P〈0．01）；各组间CQLQ差异无显著性（P〉0．05），虽然整体研究时CQLQ与FEV1％和PEFR的相关性有统计学意义（r=-0．302，0．274，P〈0．05），但各组内CQLQ与FEV1％和PEFR的相关性不确切。（2）经规范治疗后，CQLQ改变值与FEV1％和PEFR改变值之间呈显著正相关（r=0．777，0．747，P〈0．01）。结论CQLQ不宜代替FEV1％、PEFR等客观指标用于咳嗽变异性哮喘病情严重程度的判定，但可以代替FEV1％、PEFR作为咳嗽变异性哮喘疗效观察的简易指标。

Objective Research the correlation between the cough specific quality of life questionnaire between a second forced expiratory volume/FVC ratio and PEF rate variability in cough variant asthma, and its significance. Methods Randomly selected 52 cases of cough variant asthma patients as the object of study, and in accordance with the classification of asthma severity of the standard they were divided into Group A （ CVA class- Ⅰ ）, Group B （ CVA class -Ⅱ） , Group C （ CVA class- Ⅲ ） and Group D （ CVA class-Ⅳ ）. At the initial treatment and three months after the standard treatment, all subjects have finished the cough specific quality of life questionnaire（CQLQ） ,and conducted a second forced expiratory volume/ FVC ratio（ FEV1% ） and PEF rate variability （PEFR） detection. Results （ 1 ） Before therapy, FEV1% and PEFR in all groups were significant differences （ P 〈 0.05 ） ,and there was a significant negative correlation between FEV1% and PEFR （ r = - 0. 995, P 〈 0.01 ） ; CQLQ between each group were not significant differences （ P〉 0.05 ） , Although in overall group there was a certain correlation between CQLQ with FEV1% and PEFR （ r = - 0. 302,0. 274, P 〈 0.05 ）, but in each group the correlation between CQLQ with FEV1% and PEFR is inaccurate. （2）After standard treatment, there were significant positive correlations among the changes of CQLQ, FEV1 % and PEFR （ r = 0. 777,0. 747, P 〈 0.01 ） . Conclusion CQLQ can not replace FEV1% and PEFR to assess severity of patients in cough variant asthma, but be useful to monitor the effection of therapy, more economically, practically and facilely.