摘要
目的探讨一氧化氮合酶(NOS)抑制剂N-硝基-L-精氨酸甲酯(L-NAME)对大鼠线索性恐惧消退的影响。方法采用足底电击结合声音建立恐惧条件化,然后只呈现声音而无电击进行消退,建立恐惧条件化与消退模型,在消退前注射L-NAME,观察大鼠的恐惧消退学习记忆能力。结果注射L-NAME大鼠,恐惧消退学习能力明显下降。结论NOS抑制剂L-NAME损伤了大鼠的恐惧消退学习。
Objective To study the effect of nitric oxide synthase inhibitor N (G) - nitro- L- arginine methyl ester (L- NAME) on extinction of cued fear. Method Fear conditioning and extinction model was established by electric--foot accompanied with tone, then only tone but no shock. We observe the effects of pre - ex- tinction L- NAME injection on extinction learning and memory abilities. Result The extinction learning and memory of L - NAME injection rats were significantly decreased. Conclusion Nitric oxide synthase inhibitor L - NAME impaires extinction of cued fear.
出处
《南华大学学报(医学版)》
2008年第1期1-4,共4页
Journal of Nanhua University(Medical Edition)
基金
国家自然科学基金(30770689)
湖南省教育厅优秀青年基金(05B045)
南华大学博士启动基金(5-03-XJQ-03-041)