脑梗塞患者血小板活化状态的检测及临床意义

Detecting the Activated Platelets of Cerebral Infarction Patients

目的:探讨脑梗塞患者外周血活化血小板的含量以及临床意义。方法:用流式细胞仪检测脑梗塞患者活化血小板标志物PAC-1和CD62p,并与同年龄对照组比较。结果:脑梗塞患者血小板表面表达PAC-1和CD62p的血小板量为13.83±7.20和31.26±19.68,均明显高于正常对照组(P<0.01)。结论:脑梗塞患者血栓的形成与血小板的活化密切相关,活化血小板的检测可以作为脑梗塞早期诊断和病情判断的一项较特异指标。

Objective： To research the content of the activated platelets in cerebral infarction patients and its clinical significance. Methods： Flow Cytometry （FCM） is used to measure the content of platelet PAC-1, CD62p in cerebral infarction patients matching age control group. Results： The platelets＇eontent with PAC-1 and CD62p in cerebral infarction patients is 13.83 ± 7.20 and 31.26 ± 19.68 respectively, and the result has statistically significance comparing with those of the control group （ P 〈 0.01 ）. Conclusion： The formation of thrombus in cerebral infarction patients is highly related to the platelets＇ activation, which can be a diagnostic indicator of cerebral infarction diseases.