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整合子-基因盒系统与细菌多重耐药研究进展 被引量：4

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摘要 超广谱抗生素的广泛及不规范使用使得细菌耐药问题日趋严重,而获得外源性耐药基因是大多数细菌产生耐药性的原因。整合子通过整合酶介导的位点特异性重组捕获移动性基因盒,可赋予细菌新的耐药性。
作者 蒋宏 刘继芬 刘蓉
机构地区 成都中医药大学医学技术学院
出处 《四川省卫生管理干部学院学报》 2008年第2期122-125,共4页 Journal of Sichuan Continuing Education College of Medical Sciences
关键词 整合子 基因盒 细菌多重耐药性
分类号 R392.5 [医药卫生—免疫学]
  • 相关文献

参考文献25

  • 1顾兵,童明庆.整合子与细菌耐药[J].临床检验杂志,2005,23(3):226-229. 被引量：46
  • 2Martinez- Ferijo P, Fluit ADC, Schmltz FJ, et al. Many class Ⅰ integrons comprise distinct stable structures occurring in different species of Enterebacteriaceae isolated from widespread geographic regions in Europe [J]. Antimicreb Agents Chemother, 1999; 43 (3) : 686- 689.
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二级参考文献96

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共引文献50

同被引文献65

  • 1兰全学,刘衡川.整合子-基因盒系统研究进展[J].现代预防医学,2006,33(5):725-729. 被引量：3
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  • 3Hall RM, Brookes DE, Stokes HW. Site-specific insertion of genes into integrons: role of the 59-base element and determination of the recombination cross-over point. Mol Microbiol, 1991, 5(8): 1941-1959.
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  • 5Mazel D. Integrons: agents of bacterial evolution. Nat Rev Microbiol, 2006, 4(8): 608-620.
  • 6Partridge SR, Tsafnat G, Coiera E, et al. Gent cassettes and cassette arrays in mobile resistance integrons. FEMS Microbiol Rev, 2009, 33(4): 757-784.
  • 7Shibata N, Doi Y, Yamane K, et al. PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron. J Clin Microbiol, 2003,41(12):5407-5413.
  • 8Correia M, Boavida F, Grosso F, et al. Molecular characterization of a new class 3 integron in Klebsiella pneumoniae. Antimicrob Agents Chemother, 2003, 47(9): 2838-2843.
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  • 10Mazel D, Dychinco B, Webb VA, et al. A distinctive class of integron in the Vibrio cholerae genome. Science, 1998, 280(5363): 605-608.

引证文献4

二级引证文献24

四川省卫生管理干部学院学报
2008年 第2期

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