Nd(Ⅲ)-邻菲罗啉-加替沙星三元配合物的合成及与DNA的作用

Synthesis of ternary complex of Nd(Ⅲ)-1,10-phenanthroline-gatifloxacin and interaction between it and DNA

合成了1,10-二氮杂菲(phen)、加替沙星(HGA)与Nd(Ⅲ)的固态三元配合物,通过元素分析、红外光谱、1H NMR等确定了配合物的化学组成为Nd(phen)2(GA)3.H2O,配体phen及GA均以双齿螯合方式与金属离子配位,配位数为10.通过紫外光谱、荧光光谱初步研究了配合物及配体与DNA的作用.实验结果表明,配合物与DNA存在插入作用,阻止其复制或表达而起到抗菌作用.

A novel ternary complex of Nd（Ⅲ ） with 1,10-phenanthroline （phen） and gatifloxacin （GA） has been synthesized and characterized by elemental analysis, IR, 1HNMR. The composition of complex Nd （phen）2 （GA）3· H2O was determined. The ligands （phen and GA） are coordinated to the Nd（ Ⅲ ） ion in a bidentate chelating form, and the coordination number of metallic ion is ten. The spectra of fluorescence and UV showed that there are interaction between complex and DNA, The anti-microbial activity of this compound is probably related to this interaction.