透明细胞肉瘤4例病理分析

Clear Cell Sarcoma:A Pathology Study of 4 Cases

目的:探讨透明细胞肉瘤(Clear Cell Sarcoma,CCS)的临床病理特征、诊断及鉴别诊断。方法:观察4例CCS病理形态及免疫组化特征。结果:肿瘤发生在下肢3例、手指1例。组织学观察:肿瘤主要由胞质透明或淡伊红染的上皮样和短梭形细胞构成,被纤维组织分隔成巢状或条索状,核圆形或卵圆形,核仁明显,核分裂少见。1例见少量多核巨细胞。免疫组化标记:肿瘤细胞均表达HMB45、S-100蛋白及Vim。结论:CCS的诊断应结合临床与病理形态学特征,免疫组化检查有重要鉴别诊断价值。

Objective ： To investigate the clinicopathological features.diagnosxs and differential diagnosis of clear cell sarcoma（CCS）. Methods ：Pathomorphology and immunohistochemistry features were observed in 4 cases of CCS. Resuits：3 cases were located in lower limbs and 1 case occurred in finger. Histologically ,tumor was composed of polygonal or spindle-shaped cells with abundant clear or palely-staining cytoplasm and separated by fibrous septa into nests or trabs. The tumor had round to ovoid vesicular nuclei with prominent nucleoli, rarely caryocinesia. There was multinucleated giant cell in one of cases. Immunohistochemically, tumor cells were all positive for HMB45,S- 100, Vim. Conclusions ： CCS can be diagnosed by the combination of clinical data with histopathology and immunohistochemistry play an Important role in the differential diagnosis.