新洁尔灭治疗真菌性角膜病的实验病理学研究之一(动物实验的临床观察)

Observation of Experience of the Therapy with Bromogeramine for the Mycotic Keratopathy

为评价新洁尔灭（Ｇ１２）对真菌性角膜病的治疗效果，用注射法复制真菌性角膜病动物模型，并采用０．００５％Ｇ１２，对实验性真菌性角膜病进行治疗。结果表明，４０只家兔８０只眼全部出现典型的真菌性角膜病。治疗后角膜溃疡愈合情况差异显著；前房积脓，两周内差异不显著，两周后差异显著；角膜穿孔及角巩膜葡萄肿差异不显著。结论：注射法复制真菌性角膜病动物模型优于滴入法和划痕法；Ｇ１２具有减轻症状和体征并缩短病程的作用；Ｇ１２有可能成为临床治疗真菌性角膜病理想的眼局部用药。

The purpose of the present study was to investigate the effect on therapy with bromogeramine(G12)for the mycotic keratopathy.The subject was 40 rabbits,and it was used as animal model of mycotic keratopathy.The right eye was droped with 0.005% G12 for the experimental group and left eye with 0.9% NaCl for the control group.The results showed that the 80 eyes were all the mycotic keratopathy in the rabbits.There were more difference in the status of the ulcer healing of cornea between two groups.After two weeks,there were more difference in the eyes with hypopyon.It was no difference between the corneal perforation and the corneosclera staphyloma.