摘要
柯萨奇B-3m病毒(CVB3m)可诱发BALB/c小鼠急性病毒性心肌炎(VMC),本实验通过给BALB/c小鼠腹腔接种CVB3m,感染后8天VMC检出率为93.33%。应用原位末端标记法(TUNEL)及电镜检查发现:VMC伴随有心脏血管内皮细胞及心肌细胞凋亡,其阳性率为70.00%。实验结果提示:血管内皮细胞凋亡可能参与VMC的发生与发展。
An experimental acute myocarditis caused by coxsackie B 3m virus (CVB 3m ) was developed in made BALB/c mice 5 weeks of age.The animals were sacrificed at the 8th day after infection.We conducted a pathological study of the apoptosis of cardiomyocytes by the TUNEL and electron micrographs,Virus-infected mice was apoptotic degeneration of endothelium cell of small arteries in cardiac myocytes (70.00%).The results showed that CVB 3m induces apoptosis of endothelium cell of small arteries in mice,it was related to myocarditis.
出处
《哈尔滨医科大学学报》
CAS
1997年第4期278-279,共2页
Journal of Harbin Medical University