自噬与肿瘤的关系

Autophagy and tumor

在某些条件下，自噬能保护肿瘤细胞免受杀伤，而在另外的环境下自噬又具有抗肿瘤作用。在抗肿瘤药应用方面，自噬诱导细胞死亡的机制也存在很大争议。在肿瘤发生发展过程中，自噬扮演着不同角色，在不同阶段促进或抑制肿瘤生长。

In some conditions,autophagy serves a protective role;but in other conditions it has an anticancer role. There is still contradiction on the mechanisms that autophagy induces tumor cells death. During the genesis and development of tumors, autophagy has tumor promoting or inhibiting properties at different times.