放化疗所致口腔黏膜炎的干预治疗

Intervention therapy of chemoradiotherapy-induced oral mucositis

口腔黏膜炎是放化疗治疗头颈部肿瘤的常见并发症，发病率高，影响肿瘤治疗效果。其干预治疗方法有三维适形放疗、调强放疗，以尽量减少正常组织受照面积减轻症状；药物治疗方法如生长因子类药物、氨磷汀、硫酸锌、抗炎症药物、谷氨酰胺等的使用能降低黏膜炎严重程度，缩短黏膜炎病程，一定程度上改善了患者生活质量。

Oral mucositis is a common and serious complication secondary to chemo-radiotherapy for head and neck cancer that has a high morbidity and affects the treatment outcomes. Currently available interventions such as three-dimensional conformal radiotherapy and intensity-modulated radiation therapy are directed at minimizing local radiation exposure and providing symptomatic relief. Recently, a number of new treatment modalities have been expected to be introduced for reduction of severity and duration of mucositis, such as keratinocyte growth factor, amifostine, zinc sulfate, anti-inflammation agents, glutamine, etc. These efforts are likely to improve the life quality of cancer patients significantly.