还原型谷胱甘肽治疗急性胰腺炎肝损害疗效及机制探讨

Curative effect and pathogenesis of reduced glutathione in treating liver injury caused by acute pancreatitis

目的观察急性胰腺炎肝损害还原型谷胱甘肽的疗效。方法将急性胰腺炎肝损害患者分为治疗组47例,给予常规治疗和还原型谷胱甘肽,对照组42例仅给予常规治疗。两组患者检测肝功能、胰酶和血浆肿瘤坏死因子(TNF)、白介素-6(IL-6)。结果治疗1周后,两组患者肝功能和胰酶均有好转,但治疗组更为明显:治疗组TNF-α、IL-6下降明显。结论还原型谷胱甘肽对急性胰腺炎肝损害有较好的临床疗效,其机制可能与其抑制炎性介质和氧自由基作用有关。

Objective To observe the efficacy and pathogenesis of reduced glutathione in treating the liver injury caused by, acute pancreatitis. Methods 89 cases were divided into two groups. 47 cases in treatment group who received routine treatment and reduced glutathione, 42 cases in control group who received routine treatment. Liver function, pancreatic enzyme indexes, serum tumor necrosis factor （TNF） and interleukin-6 （IL-6） were determined in sera from the two groups. Resulfs After treatment, liver function and pancreatic enzyme indexes were improved in both groups, but it was obvious in treatment group （P〈0.05）; Levels of TNF and IL-6 were decreased significantly in treatment group （P〈0.05）. Conclusion Reduced glutathione has beneficial effects on the treatment of the liver injury caused by acute pancreatitis. The effects of inhibiting of the inflammatory medium and oxygen free radical may be involved in the mechanism.