芪黄汤对大鼠局灶性脑梗塞脑保护作用

Effect of Qihuang Decoction Preventing the Focal Cerebral Infarction of Rats

目的:观察芪黄汤对局灶性脑梗塞大鼠的脑保护作用。方法:选用Wistar大鼠50只,随机分为5组,即正常对照组、模型组、芪黄汤大剂量组、芪黄汤中剂量组和芪黄汤小剂量组,采用芪黄汤事先灌胃周,再对模型组和芪黄汤组大鼠运用栓线法制作局灶性脑梗塞的模型,检测血清中MDA(丙二醛)和NO(一氧化氮)的含量及观察脑组织形态学变化。结果:经芪黄汤治疗的局灶性脑梗塞大鼠血清MDA和NO非常显著降低(P<0.01),光学显微镜下观察脑组织形态学有明显好转的变化。结论:芪黄汤可有效地降低大鼠血清MDA和NO含量,改善脑组织结构,对局灶性脑梗塞大鼠大脑起到保护作用。

Objective：To study the mechanism of Qihuang decoction which prevents thefocal cerebral infaratlon of the rats. Mothods：Fifty Wistar rats were randomly divided into five groups：the normal group, the model group, the treated group by Qihuang decoction with the small dosage,the medium dosage, the big dosage;After administrated for one week with Qihuang decoction,the models of the focal cerebral infaration of the rats were made by putting the special thread to the internal carotid artery. The microstructure change of rats brain tissue was observed and the content of the malondialdehyde（MDA） and the nitrogen monoside（NO） in the serum. Results：The content of the MDAand NO in the serum in the Qihuang groups were markly decline （P 〈 0. 01 ）, and the microstructure rats brain tissue were significantly improved. Conclusion：Qihuang decoction can prevent the focal cerebral infarction.