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吸入性麻醉药对肾脏缺血／再灌注损伤的影响 被引量：1

Effects of inhalational anesthetics on renal ischemia/reperfusion injury
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摘要 吸入性麻醉药对肾脏缺血／再灌注损伤的保护机制可能是通过亚中毒浓度无机氟化物的直接作用，抑制胞质膜的损伤，对丝裂原活化蛋白激酶家系（MAPKs）的影响，免疫调节和促进热休克蛋白70（HSP-70）合成实现的。而不是通过对肾血流的影响和对肾脏KATP通道的激活作用。 Inhalational anesthetics may provide protection against renal ischemia/reperfusion injury through the following mechanisms- directly affect the sub - lethal density of fluoride, activate the renal cortical spingomylinase cascade and inhibit the activity of PLA2 in kidney, influence the mitogen -activated protein kinases （MAPKs）, moderate immune reaction, and upregulate the synthesis of HSP - 70 in kidney. The role of the change in renal blood flow and the activation of the KATe channel in kidney is not considered to be linked with this protection.
作者 王江梅 胡智勇
机构地区 浙江大学医学院附属儿童医院麻醉科
出处 《国际麻醉学与复苏杂志》 CAS 2008年第3期209-212,共4页 International Journal of Anesthesiology and Resuscitation
关键词 肾脏 缺血 再灌注损伤 吸入性麻醉药 kidney ischemia reperfusion injury inhalational anesthetics
分类号 R96 [医药卫生—药理学]
  • 相关文献

参考文献27

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二级参考文献27

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共引文献13

同被引文献13

  • 1Obal D, Dettwiler S, Favoccia C, et al. The influence of mitochondrial KATP-channels in the cardioprotection of preconditioning and postconditioning by sevoflurane in the rat in vivo. Anesth Analg ,2005 , 101 : 1252-1260.
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国际麻醉学与复苏杂志
2008年 第3期

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