丝裂原活化蛋白激酶与糖尿病性神经病理性疼痛

MAPK and diabetic neuropathic pain

糖尿病性神经病理性疼痛（diabetic neuropathic pain，DNP）是糖尿病最常见的慢性并发症之一。其发病机制未明，至今仍缺乏疗效确切且安全的治疗方法。丝裂原活化蛋白激酶（mitogen-activated protein kinases，MAPK）信号转导通路是细胞外信号从细胞表面传导至细胞核内部的重要传递途径，在神经细胞的可塑性过程中发挥重要作用。糖尿病时，高血糖被认为是DNP发病的重要病理生理学基础，与其他因素一起激活MAPK信号转导通路，使神经元功能和结构发生可塑性改变，导致DNP的发生。

Diabetic neuropathic pain （DNP） is considered as one of the most common chronic complications of diabetes. We still do not understand its pathogeneses and also lack safe and effective therapeutic methods. Mitogen -activated protein kinases （MAPK） is an important transduction pathway in signals transmitted from extracellular to intracellular, and also plays a crucial role in neuronal plasticity. In diabetes, hyperglycosemia is considered as the main pathophysiologic basis of DNP by activation of MAPK signal transduction pathway along with other factors and by both constructral and functional modifications in neuronal plasticity.