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心脏移植中供心保护新策略

New strategies in donor heart protection
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摘要 心脏移植是现代医学对临床治疗无效的晚期或进展期心脏病惟一可行的治疗方法。供心保护是在常规心脏手术心肌保护的基础上发展起来的,贯穿于供心采集和移植吻合的各个环节之中,包括能量状态保护、能量资源保护以及结构保护,以期为受体提供一个具有活力和最大潜能的心脏。良好的供心保护,不仅直接提高移植的成功率,改善移植后的远期疗效,而且可以延长保存时间,扩大供心来源。此文结合当前心肌保护领域的研究热点阐述了各阶段供心保护的策略。 Heart transplantation is the only method to treat terminal heart disease in modem medicine and donor heart protection plays a key through the whole process. This review summarizes the cutting - edge issues in donor heart protection during heart transplantation and introduces the strategies in each specific stage like heart collection, transport to the destination, and surgical transplantation.
作者 杨柳青 喻田
出处 《国际麻醉学与复苏杂志》 CAS 2008年第3期260-264,共5页 International Journal of Anesthesiology and Resuscitation
基金 国家自然科学基金(项目编号:30460132)
关键词 供体 心脏保存 缺血预处理 钾通道开放剂 donor heart preservation ischemic preconditioning potassium channel openers
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