一氧化碳和硫化氢在颈动脉体缺氧反应中的调节作用

Hypoxia responses led by carotid body is regulated by carbon monoxide and hydrogen sulfide

传统认为一氧化碳和硫化氢为有毒气体，但近年的研究表明在颈动脉体感受低氧的过程中，这两种气体起重要的调节作用。一氧化碳通过增加内向钾离子电流抑制窦神经；硫化氢供体硫氢化钠则呈剂量依赖性兴奋窦神经，并且一氧化碳供体能完全逆转硫化氢对窦神经的兴奋作用。因而，一氧化碳和硫化氢共同调节颈动脉体对低氧状态反应的信号转导。

Carbon monoxide and hydrogen sulfide, both of which are well known toxic agents, are now demonstrated as critical gaseous mediators in carotid body when it responds to hypoxia. While carbon monoxide reduces sinus nerve impulses by decreasing inward potassium ion flux, sodium hydrosulfide, a donor of hydrogen sulfide, exerts an opposite effect in a dose - dependent manner. However, the exciting effect of hydrogen sulfide will be reversed completely after the donor of carbon monoxide is subjected. In this way, carbon monoxide and hydrogen sulfide intermingle into the regulation to the hypoxic information transduction.