高血糖对机体的影响及围术期血糖控制的研究进展

Detrimental effects of hyperglycemia and perioperative hyperglycemia control

许多研究表明，对于外科及危重病领域的糖尿病患者，高血糖的出现常与临床不良预后密切相关。对围术期糖尿病患者出现的高血糖进行合理调控，是临床医生面临的又一挑战。多数研究提示，严格血糖控制可以改善死亡率；但是严格血糖控制确实会增加低血糖的风险。尽管绝大多数低血糖事件影响较轻，也极少导致严重的不良后果，但在严格控制血糖的过程中，仍会对发生低血糖产生顾虑。文章回顾了高血糖对机体的不良影响，并提供了围术期血糖控制的最新研究进展。

Many studies have demostrated that hyperglycemia is associated with adverse outcomes in surgical and critically ill dia- betic patients. Most studies suggest that aggressive glycemic control may reduce morbidity and mortality. However, intensified glucose control is also associated with an increased risk of hypoglycemia. Although most hypoglycemic events are mild without significant clinical consequences, there are still worries about this problem in clinical scenarios. This review intuoduces the deleterious effects of hyperglycemia to the body and provides some recent studies in perioperative hyperglycemia control.