芒果苷对垂体后叶素诱发小鼠心肌缺血的保护作用

Effects of Mangiferin on myocardial ischemia induced by pituitrin in mice

目的观察芒果苷(mangiferin)对垂体后叶素(pituitrin,PIT)诱发小鼠心肌缺血的影响。方法采用腹腔注射PIT 30u/kg建立小鼠急性心肌缺血模型,观察芒果苷对小鼠Ⅱ导联心电图(ECG),心肌超氧化物岐化酶(SOD),丙二醛(MDA)及血清磷酸肌酸激酶(CK)和乳酸脱氢酶(LDH)的影响。结果芒果苷对PIT诱发小鼠Ⅱ导联ECG异常有改善(P<0.05)。芒果苷使心肌SOD活性明显升高,使心肌MDA含量、血清CK及LDH水平降低(P<0.05或0.01)。结论芒果苷对垂体后叶素诱发小鼠心肌缺血的损伤有保护作用。

Objective duced by pituitrin （PIT）. To evaluate the Methods Acute protection of mangiferin （MAN） myocardial ischemic models were against mice myocardial ischemia inobtained by intra- peritoneal administration of PIT 30u/kg in mice. Meanwhile, the mice were also intraperitoneal admnistration with different concentrations of MAN once daily for 7 days. The fluctuations of lead II on ECG, the myocardial SOD and MDA, the serum levels of LDH and CK were measured. Results MAN could ameliorate the abnormal changes of ECG （ P 〈 0.05）, and up - regulate SOD activity, down - regulate myocardial MDA, serum CK and LDH levels （ P 〈 0.05 or 0.01）. Conclusion MAN can protect against myocardial ischemia induced by PIT in mice.