枫叶煎剂对小鼠镇痛抗炎作用的实验研究

Experimental studies of analgesic and anti-inflammatory effects of water extracts of Folium Liquidambaris on mice

目的观察枫叶煎剂对小鼠的镇痛抗炎作用。方法镇痛实验采用醋酸致小鼠扭体法和小鼠热板法。抗炎实验采用二甲苯致小鼠耳廓肿胀法和鸡蛋清致小鼠足趾肿胀法。结果枫叶煎剂灌胃可减少醋酸致小鼠扭体的次数,扭体抑制率为67.43%,延长小鼠舔后足潜伏期,减轻二甲苯致小鼠耳廓肿胀程度和鸡蛋清致小鼠足趾肿胀程度(P均<0.01)。结论枫叶煎剂对小鼠具有镇痛抗炎作用。

Objective To investigate the analgesic and anti- inflammatory effects of water extracts of Folium liquidambaris on mice. Methods The analgesic experiments including mice writhing induced by acetic acid and mice hot - plate procedures. The anti - inflammatory experiments concluded mice ear - swollen induced by xylene and egg white - induced toe swollen. Results The intra - gastric administration of water extracts of Folium liq-uidambaris resulted in writhing reduction markedly, the inhibitory rate was 67.43 %. The water extracts could increase the pain threshold in mice induced by hot plate, and suppress the mice ears swelling induced by xylene and mitigate the mice toes swelling induced by egg white （ P 〈 0.01）. Conclusion The water extracts of Folium liquidambaris have analgesic and anti - inflammatory effects.