334株铜绿假单胞菌的耐药性分析

Analysis of Drug Resistance of 334 Strains of Pseudomonas Aeruginosa

目的:了解铜绿假单胞菌的耐药性,为临床合理选择抗菌药物提供参考。方法:回顾性总结2006年北京天坛医院铜绿假单胞菌的分布情况及耐药性。结果:临床分离的334株铜绿假单胞菌对亚胺培南的耐药率已达到39.8%;铜绿假单胞菌主要来自神经内科、呼吸科和神经外科,3个科室分离的铜绿假单胞菌对亚胺培南的耐药率以呼吸科最严重,已达到48.3%,其次为神经内科(40.2%),神经外科的耐药率最低(17.0%)。结论:北京天坛医院临床分离铜绿假单胞菌对亚胺培南耐药率较高,不同科室分离的铜绿假单胞菌对抗菌药物的耐药状况不同,提示医院宜对重点科室的重点菌种进行耐药监测,以控制耐药菌株的产生。

OBJECTIVE： To study the drug resistance of pseudomonas aeruginosa so as to provide references for rational use of antibiotics in the clinic. METHODS： The clinical distribution and the susceptibility test results of pseudomonas aeruginosa isolated from Beijing Tiantan Hospital in 2006 were analyzed retrospectively. RESULTS： The resistance rate of 334 strains to imipenem stood at 39.8%. The pseudomonas aeruginosa strains were mainly isolated from three important departments （neurological, respiratory and neurosurgery）, the resistance rates to imipenem in the above three departments in descending order were as follows： department of respiratory （48.3%）, department of neurological （40.2%）, and neurosurgery （17.0%）. CONCLUSION： The Pseudomonas aeruginosa isolated from Beijing Tiantan Hospital were highly resist to imipenem reduced and the strains isolated from different department varied in bacterial resistance, suggesting the drug resistance of antimicrobial surveillance should be emphasized in some key departments to keep the drug resistance under control.