98例氨基糖苷类抗生素致过敏反应的文献分析

Allergic Reactions Induced by Aminoglycosides: Literature Analysis of 98 Cases

目的：探讨氨基糖苷类抗生素致过敏反应的，临床特点及一般规律。方法：收集1990年1月～2007年6月国内医药学术期刊报道的氨基糖苷类抗生素致过敏反应的病例98例，并进行统计、分析。结果：氨基糖苷类抗生素引起的过敏反应与给药方式、不合理用药、药物过敏史等密切相关。结论：广大医药工作者应对氨基糖苷类抗生素引起的过敏反应给予高度的重视，坚持合理用药。

OBJECTIVE： To discuss the clinical characteristics and the patterns of allergic reaction（ADR） caused by aminoglycosides. METHODS： 98 ADR cases induced by aminoglycosides were retrieved from domestic journals reported from Jan. 1990 to June 2007 for a statistical analysis. RESULTS： The ADR of aminoglycosides was closely related to route of administration, unreasonable application, allergic history, etc. CONCLUSION ： The ADR of aminoglycosides and rational use of aminoglycosides should be strengthened further in the clinical practice.