摘要
[目的]探讨胃癌14-3-3sigma mRNA的表达及其与胃癌生物行为学关系。[方法]用半定量RT-PCR检测胃癌患者肿瘤组织和远癌组织标本中的14-3-3sigma mRNA。[结果]39.6%(21/54)的胃癌组织中的14-3-3sigma mRNA出现低表达,但14-3-3sigma mRNA的低表达与患者的性别、年龄以及胃癌的病理分型、分期以及淋巴结转移均无显著性相关。[结论]14-3-3sigmamRNA的低表达与胃癌的发生相关。
[Purpose ] To investigate expression of 14-3-3 sigma mRNA in gastric cancer and its significance. [Methods] Expression of 14-3-3 sigma mRNA in gastric cancer and normal tissues far from tumor was semi-quantitated by RT-PCR. [Results] Low expression of 14-3-3 sigma mRNA in gastric cancer accounted for 39.6%（21/54）. Low expression of 14-3-3 sigma mRNA in gastric cancer wasn＇t correlated with gender, age, histological types, stages and lymphatic metastasis. [Conclusion ] Low expression of 14-3-3 sigma mRNA is related to carcinogenesis in gastric cancer.
出处
《中国肿瘤》
CAS
2008年第7期627-628,共2页
China Cancer
基金
安徽省教育厅自然科学基金(2006KY127C)
安徽省教育厅高校青年教师基金(2006jq1177)
