微管连续流快速合成13个查耳酮

Quick Synthesis of Thirteen Chalcones in a Continuous Flow Capillary Microreactor

使用壁厚为1～1．5μm，断面内径为0．5～1．5mm的玻璃毛细管，制作了简易微管连续流反应器。利用该连续流反应器合成了13个查耳酮，并应用IR和^1H NMR谱对所合成的化合物进行了结构表征。结果表明，在40kHz的超声波作用下，反应温度26～38℃，使用该反应器合成查耳酮的产率可高达80％～90％，与传统的烧瓶反应相比，反应时间由原来的1～6h缩短到10min左右。该法反应产率高、反应时间短，可以连续、大规模合成查耳酮。

A simple continuous flow capillary microreactor was made with the capillary glass tube having a wall thickness of 1 - 1.5μm and inside diameter of 0. 5 - 1.5 mm. Thirteen chalcones were synthesized and characterized by IR and ^1H NMR. The yields of chalcones are up to 80% - 90% under ultrasonic irradiation at 40 kHz and 26 - 38 ℃ using this continuous flow microreactor. Compared with the traditional synthesis in flask,the reaction time was reduced to 10 min from 1 - 6 h. This synthesis approach not only has advantages of high yields and short reaction time but also can synthesize chalcones continuously and on a large scale.