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一个基于复制变异准则的蛋白质作用网络的构建模型

A Model of Protein Interaction Network Based on Duplication and Divergence Mechanisms
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摘要 本文主要根据生物学的复制和变异的基本原理,提出了具有反偏爱复制特性的一个蛋白质作用网络的新的演化模型.通过计算,发现所得的网络与实测的蛋白质作用网络的某些拓扑性质能够很好的吻合.生成的网络不仅是稀疏的,而且具有小世界性和无标度(scale-free)性质. In this paper, we mainly propose a new evolving protein interaction network model charactered by anti-preference based on the basic principles of biological duplication and divergence. Through calculation, we find that some topological properties of our network match measured protein interaction network well. The network generated by us is not only sparse, but also is small-world and scale-free.
出处 《应用数学与计算数学学报》 2008年第1期120-124,共5页 Communication on Applied Mathematics and Computation
基金 国家自然科学面上项目基金(项目编号:10372054和10372054)重点项目基金(项目编号:70431002) 上海大学研究生创新基金
关键词 蛋白质作用网络 复制 变异 小世界性质 无标度性质 protein interaction network, duplication, divergence, the small-world property, the scale-free property
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参考文献10

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