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红树林共生真菌Paecilomyces sp. Tree 1-7代谢产物对人肝癌细胞HepG2的杀伤作用 被引量：3

Cytotoxicity of the Secondary Metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1-7 on Human Hepatoma Cell Line HepG2
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摘要 目的:测定红树林共生真菌Paecilomycessp.Tree 1-7代谢产物对人肝癌细胞HepG2的杀伤作用。方法:实验分为3组:空白对照组、阳性对照组和代谢产物组,采用MTT法检测不同浓度的代谢产物对人肝癌细胞HepG2的杀伤作用。结果:代谢产物中化合物secalonic acid A对人肝癌细胞HepG2的IC50为2.0μg/ml,tenellic acid A对HepG2的IC50为62.1μg/ml,alternin对HepG2的IC50为7.0μg/ml。结论:红树林共生真菌Paecilomycessp.Tree 1-7代谢产物中secalonic acid A和alternin对人肝癌细胞HepG2具有较强的细胞毒性,值得进一步研究。 Objective ： To study the cytotoxicity of the seeondary metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1- 7 on human hepatoma cell line HepG2 cultured in vitro. Methods：Three groups were divided：compounds group,5-Fu group and control group. The cytotoxicity was measured by MTT method when HepG2 cells were treated by different concentration of the secondary metabolites of Paecilorayces sp. Tree 1-7. Results：Secalonic acid A, tenellic acid A and alternin inhibited the growth of human hepatoma cell line HepG2,the IC50 separately were 2.0,62. 1 and 7. 0 μg/ml. Conclusion：Secalonic acid A and ahernin have strong cytotoxicity on HepG2 cultured in vitro.
作者 蔡小玲 高俊平 李庆 温露 佘志刚 林永成
机构地区 中山大学化学与化学工程学院
出处 《中药材》 CAS CSCD 北大核心 2008年第6期864-865,共2页 Journal of Chinese Medicinal Materials
基金 国家高科技发展(863)资助项目(2006AA09Z422) 国家自然科学基金项目(20572136) 广东省自然科学基金项目(5300528) 中山大学青年教师基金资助项目(2005310001131133)
关键词 红树林共生菌 人肝癌细胞HEPG2 细胞毒性 Marine Mangrove Fungus Paecilomyces sp. Human hepatoma cell line HepG2 Cytotoxicity
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献7

  • 1Ananda K, Sridlhar K R. Diversity of endophytie fungi in the roots of mangrove species on the west coast of India. Canadian Journal of Microbiology, 2002,48 ( 10 ) 871- 875.
  • 2温露,林永成,赵丽冰,佘志刚,蔡小铃,郑忠辉.红树林共生真菌Paecilomyces sp· Tree 1-7代谢产物的研究[J].中药材,2006,29(8):782-785. 被引量：3
  • 3温露,郭志勇,佘志刚,林永成,VRIJMOED L L P.一株南海海洋真菌Sporothrix sp.#4335的甾体类代谢产物研究[J].广东药学院学报,2006,22(6):613-614. 被引量：2
  • 4Kurobane I, Iwahashi S, Fukuda A. 1 Cytostatic activity of naturally isolated isomers of secalonic acids their chemically rearranged dimmers. Drugs under Experimental and Clinical Resarch, 1987,13(6) :3391.
  • 5Kurobane I, Vining LC, Mclnnes AG. 1 Biosynthetic relationships among the secalonic acids, Isolation of emodin, endocmcin and secalonic acids from Py renochaeta terrestris and Aspergillus aculeatus. Journal of Antibiotics, 1979,32 (12) : 12561.
  • 6Hyuneheol Oh, Tae Oh Kwon, Gler J. B. , et al. Tenellie AeidsA-D: New Bioaetive Diphenyl Ether Derivatives from the Aquatic Fungus Dendrospora tenella. Journal of Natural Products, 1999,62(4) :580.
  • 7Jung HA, Chung HY, Yokozawa T, et al. Alaternin and emodin with hydroxyl radical inhibitory and /or seavengingaetivities and hepatop rotective activity on taerine induced eytotoxieity in HepG2 cells. Archives of Phamlaeal Research, 2004,27 ( 9 ) : 947.

二级参考文献11

  • 1Lin Y C, et al. Penicillazine, a unique quinolone derivative with 4H-5,6-dihydro-1,2-oxazine ring system from the marine fungus Penicillium sp. (#386)from the South China Sea. Tetrahedron, 2000,56(49) :9607.
  • 2Lin Y C, et al. A novel N-cinnamoyl-cyclopeptide containing an allenic ether-from the fungus Xylaria sp. (#2508)from the South China Sea. Tetrahedron Letters, 2001,42 :449.
  • 3Lin Y C, et al. The metablites of the mangrove fungus Verruculina enalia No. 2606 from a salt lake in the Bahamas.Phytochemistry, 2002,59:469.
  • 4Kurobane, I, et al. Cytostatic activity of naturally isolated isomers of secalonic acids and their chemically rearranged dimers. Drugs under Experimental and Clinical Resarch,1987,13(6) :339.
  • 5Hyuncheol Oh, et al. Tenellic Acids A-D: New Bioactive Diphenyl Ether Derivatives from the Aquatic Fungus Dendrospora tenella. Journal of Natural Products, 1999,62(4) :580.
  • 6Itsuo Kurobane, et al. Biosynthetic relationships among the secalonic acids. Isolation of emodin, endocrocin and secalonic acids from Pyrenochaeta terrestris and Aspergillus aculeatus. Journal of Antibiotics, 1979,32 (12) : 1256.
  • 7SAHAR E M,MESALHY R M,NORIO N,et al.Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum[J].Phytochemistry,1998,49(6):1651-1657
  • 8LIN Y C,SHAO Z Y,JIANG G C et al.Penicillazine,a unique quinolone derivative with 4H-5,6-dihydro-1,2-oxazine ring system from the marine fungus Penicillium sp.(#386) from the South China Sea[J].Tetrahedron,2000,56:9607-9609.
  • 9LIN Y C,WU X Y,FENG S,et al.Five Unique Compounds:Xyloketals from Mangrove Fungus Xylaria sp.from the South China Sea Coast[J].J Org Chem,2001,66:6252-6256.
  • 10CHEN G Y,LIN Y C,WEN L,et al.Two new metabolites of a marine endophytic fungus (No.1893) from an estuarine mangrove on the South China Sea coast[J].Tetrahedron,2003,59:4907-4909.

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同被引文献40

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二级引证文献14

中药材
2008年 第6期

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