注射用脉络宁对大鼠血栓闭塞性脉管炎模型的治疗作用

Effect of Mailuoning Injectable Powder on Experimental Vascular Occlusion Angeitides in Rats

目的:观察注射用脉络宁对血管闭塞性脉管炎大鼠模型的影响。方法:采用月桂酸股动脉注射造成大鼠血栓闭塞性脉管炎模型,观察大鼠的体征变化、病理切片血栓分级及对血液流变学指标的影响。结果:注射用脉络宁能减少血管内血栓形成的数量,改善血液流变。结论:注射用脉络宁对实验性血栓闭塞性脉管为大鼠模型具有较好的治疗作用,其机理与改善血液流变学、增强血管的抗血栓功能有关。

Objective：To investigate the effect of Mailuoning injectable powder on experimental vascular occlusion angeitides in rats. Methods ： Rats were injected laurostearic acid into arteria cruralis to induce the model of experimental vascular occlusion angeitides, then we observed the changes of objective sign of rats, and analysed throm ranking through pathological section under electro-micro- scope. Results ： Mailuoning injectable powder could decrease the quantity of throm in blood vessel, and improve hemorrbeoiogy. Conclusion ：The results show that Mailuoning injectable powder has obvious therapeutical effect on experimental vascular occlusion angeitides in rats, and its mechanism may be related to the anti-throm in blood vessel and improving hemorrbeology.