羟氯喹在风湿病治疗中眼部不良反应的初步调查

Preliminary investigation of eye disorders occurring with hydroxychloroquine in treating rheumatic diseases

目的:调查羟氯喹在风湿病治疗中出现的眼部不良反应。方法:对2003年1月至2007年6月我院83例使用羟氯喹的风湿病患者所发生不良反应的类型和发生率进行调查。结果:83例患者所使用羟氯喹的初始剂量为200～400mg/d,之后按病情减量为100～200mg/d。83例中有12例发生不良反应,其中眼部反应5例(6.0%),神经系统反应为3例(3.6%),消化道反应2例(2.4%),皮疹1例(1.2%),以及水肿1例(1.2%)。在接受视野检查的14例患者中,1例视野缺损很可能与羟氯喹有关,另1例可能有关。结论:羟氯喹治疗风湿病可引起眼部不良反应,反应程度较轻,停药或减少剂量后症状改善。

Objective： To investigate the eye disorders induced by hydroxychloroquine in treating rheumatic diseases. Methods： Eight-three hydroxychloroquine-treated patients with rheumatic diseases in our hospital were investigated from January 2003 to June 2007. The type and frequency of adverse reactions associated with hydroxychloroquine were analysed. Results： The initial dosage of hydroxychloroquine used in 83 patients was 200 -400 mg/d, subsequent dosage was decreased to 100 -200 mg/d. Of the 83 patients, 12 developed adverse reactions as follows： 5 cases （6.0%） of eye disorders, 3 cases （3.6%）of neurological disorders, 2 cases （2.4%） of gastrointestinal disorders, 1 case （ 1. 2% ） of skin rash, and 1 case （ 1.2% ） of oedema. Of the 14 patients receiving visual field testing, one patient＇s visual field defect probably related to hydroxychloroquine, and another patient＇ s visual field defect possibly related to hydroxychloroquine. Conclusion： Hydroxychloroquine might induce eye disorders. It is relatively mild in severity, and improve after stopping hydroxychloroquine or decreasing its dosage.