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国产齐拉西酮治疗精神分裂症的临床观察 被引量：5

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摘要 盐酸齐拉西酮是一种新型的非典型抗精神病药，为D2、5羟色胺（5-HT）2A、5-HL和5-HT1受体强有力的拮抗剂，又是5-HT1A受体的激动剂，同时还是5-HT和去甲肾上腺素（NE）的再摄取抑制剂。该药可用于治疗精神分裂症和分裂情感性精神障碍的阳性症状、阴性症状、认知症状和情感症状等，也用于精神分裂症维持治疗，对双相情感障碍和难治性精神分裂症也有效。本试验旨在进一步观察该药的临床疗效和安全性。
作者 孙俊伟 王斌红 王红霞
机构地区 山西省精神卫生中心早期干预科 长治精神卫生中心精神科
出处 《中国药物与临床》 CAS 2008年第7期562-565,共4页 Chinese Remedies & Clinics
关键词 难治性精神分裂症 盐酸齐拉西酮 维持治疗 临床观察 5-HT1受体 分裂情感性精神障碍 非典型抗精神病药 5-HT1A受体
分类号 R749.3 [医药卫生—神经病学与精神病学] R971.4 [医药卫生—药品]
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参考文献9

  • 1Stahi SM, Shayegan DK, The psychopharmacology of ziprasidone: receptor-binding properties and/real-wold psychiatric practice. J Clin Psychiatry, 2003,4 Suppl 19: 6-12.
  • 2Caley CF,Coopek CK. Ziprasidone: the fifth atypical antlpsytchotic. Ann Plmrmacother,2002,36(5): 839-851.
  • 3Neneroff CB, Lieberman JA, Weiden PJ, et al. From clinical research to clinical practice: a 4-year review of ziprasidone. Cns Spectr, 2005, 10(11): S1-S20.
  • 4Potkin SG, Keck PE Jr, Segal S, et al. Ziprasidone in acute bipolar mania: a 21day randomized, double-blind, placebo-controlled replication trial. J Clin Psycho pharmaeol, 2005, 25 (4): 301-310.
  • 5Kane JM, Khanna S, Raiadhyaksha S, et al. Efficacy and tolerability of ziprasidone in patients with treatment-resistant schizophrenia. Int Clin Psychopharmacol, 2006, 21(1): 21-28.
  • 6Simpson GM, Glick ID, Weiden PJ, et al. Randomized,controlled, double--blind muhicenter comparison of the efficac and tolerability of ziprasidone anti olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder. Am Psychiatry, 2004,161(10): 1837-1847.
  • 7Ohe JP, Spina E, Murray S, et al. Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia results of a 12-week, double-blind study. Int Clin Psychophar Macol,2006, 21(3): 143-151.
  • 8Mamo D, Kapur S, Shammi CM, et al. A PET study odopamine D2 and serotonin 5-HT~ receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone. Am J Psychiatry, 2004, 161(5): 818-825.
  • 9李华芳,谢世平,李鸣,张明廉,李静,苏炳华,顾牛范.齐拉西酮治疗精神分裂症的随机、双盲、双模拟、多中心研究[J].中国新药与临床杂志,2006,25(10):747-752. 被引量：68

二级参考文献12

  • 1STAHI SM, SHAYEGAN DK. The psychopharmacology of ziprasidone: receptor-binding propreties and real-world psychiatric practice[J]. J Clin Psychiatry, 2003,64 Suppl 19 : 6-12.
  • 2CALEY CF, COOPER CK. Ziprasidone: the fifth atypical antipsychotie[J]. Ann Pharmaeother. 2002, 36(5 ) : 839-851.
  • 3KANE JM. Oral ziprasidone in the treatment of schizophrenia: a review of short-term trials[J]. J Clin Psychiatry, 2003, 64 Suppl 19:19-25.
  • 4HARVEY PD, SIU CO, ROMANO S. Randomized, controlled,double-blind, multicenter comparison of the cognitive effects of ziprasidone versus olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder[J]. Psychopharmacology, 2004, 172(3) :324-332.
  • 5HIRSCH SR, KISSLING W, BAUML J, et al. A 28-week comparison of ziprasidone and haloperidol in outpatients with stable schizophrenia[J]. J Clin Psychiatry, 2002, 63 (6) : 516-523.
  • 6NEMEROFF CB, LIEBERMAN JA, WEIDEN PJ, et al. From clinical research to clinical practive: a d-year review of ziprasidone[J]. CNS Spectr, 2005, 10( 11 ) :s1-s20.
  • 7POTKIN SG, KECK PE Jr, SEGAL S, et al. Ziprasidone in acute bipolar mania: a 21-day randomized, double-blind, placebocontrolled replication trial[J]. J Clin Psyehopharmacol, 2005,25(4) :301-310.
  • 8KANE JM, KHANNA S, RAIADHYAKSHA S, et al. Efficacy and tolerability of ziprasidone in patients with treatment-resistant schizophrenia[J]. Int Clin Psychopharmacol, 2006, 21 ( 1 ) :21-28.
  • 9SIMPSON GM, GLICK ID, WEIDEN PJ, et al. Randomized,controlled, double-blind multicenter comparison of the efficacy and tolerability of ziprasidone and olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder[J]. Am J Psychiatry, 2004, 161 (10) : 1837-1847.
  • 10OLIE JP, SPINA E, MURRAY S, et al. Ziprasidone and amisulpride effectively treat negative symptoms of schizophrenia: resuits of a 12-week, double-blind study[J]. Int Clin Psychopharmacol, 2006, 21(3):143-151.

共引文献67

同被引文献22

引证文献5

二级引证文献18

中国药物与临床
2008年 第7期

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