羟乙基淀粉对失血性休克大鼠复苏效果的影响

Effects of hydroxyethyl starch at different molecular weights on hemorrhagic shock in rats

目的比较不同相对分子质量的6%羟乙基淀粉(hydroxyethyl starch,HES)/0.9%NaCl溶液对大鼠失血性休克的复苏效果。方法SD大鼠制作45%放血失血性休克模型,观察相对分子质量为40、130、200的HES40、HES130、HES200对休克动物平均动脉血压(mean arterial blood pressure,MAP)、血流动力学和血气指标的影响,同时观察存活时间和24h存活率,并以万汶和贺斯作为对照组。结果自制不同相对分子质量HES可以改善MAP、左心室收缩压(left in-traventricular systolic pressure,LVSP)、左心室压力上升或下降的最大速率(maximal change rate of left intraventricular pres-sure,±dp/dtmax)等血流动力学指标,效果与血气贺斯组相当,HES130和HES200组动物存活时间略高于HES40,其中以HES200效果最好,与万汶和贺斯效果相当。结论3种不同相对分子质量的HES均具有明显抗失血性休克作用,其中以HES200效果更明显。

Objective To compare the resuscitation effect of 6% hydroxyethyl starch （HES） of different molecular weight in normal saline on hemorrhagic shock in rats. Methods Hemorrhagic shock model was established in 50 SD rats by 45% hemorrhage, and then they were equally divided into 5 groups. The rats were administered with HES40/, HES130/, HES200/nonnal saline, Voluven or Haes. Their mean arterial blood pressure （MAP）, left intraventricular systolic pressure （LVSP）, the maximal change rate of left intraventricular pressure （± dp/dt ） of hemorrhagic shock rat were observed. Meanwhile, the artery blood gas, the survival time and 24-hour survival rate were also observed. Results Similar hemodynamic parameters values were obtained in the rats treated with our HES and those with Voluven or Haes. HES130 and HES200 prolonged the survival time of shocked animals in comparison with HES40. Among the 3 types of HES, HES200 had the best effect, which is equivalent to Voluven and Haes. Conclusion HES of 3 molecular weights have beneficial effect on hemorrhagic shock, and HES200 exerts best.