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3-(二甲基叔丁基硅氧基)戊二酸酐的合成 被引量：1

Synthesis of 3-(tert-Butyldimethylsilyloxy)glutaric anhydride
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摘要 介绍了以柠檬酸为起始原料合成3-(二甲基叔丁基硅氧基)戊二酸酐的方法。该路线经脱羧反应、加氢还原、羟基保护、酯水解和再闭环,以总收率为30.3%得到目的产物。同时讨论了合成过程中发烟硫酸的浓度、加氢还原的催化剂、反应时间对环合收率的影响,得到合成3-(二甲基叔丁基硅氧基)戊二酸酐的的适宜条件。认为该法工艺路线简单,是适合工业生产的合成路线。 3-（tert-Butyldimethylsilyloxy）glutaric anhydride, as an important drug intermediate, is synthesized from citric acid by decarboxylation, reduction, hydroxyl protection, esterolysis, cyclization, with the total yield of 30.3%. The effects of the concentration of fuming sulfuric acid, hydrogenation catalysts, reaction time on cyclization are also investigated, and the optimum condition of this synthesis is got. The results show that this simple technique has many advantages in industry.
作者 蒋成君 高波 盛绿青
机构地区 浙江科技学院生物与化学工程学院 浙江新东港药业股份有限公司
出处 《浙江科技学院学报》 CAS 2008年第2期107-109,共3页 Journal of Zhejiang University of Science and Technology
关键词 柠檬酸 脱羧反应 氢化 闭环 citric acid decarbaoxylic reation hydrogenation cyclization
分类号 TQ242.1 [化学工程—有机化工]
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共引文献5

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浙江科技学院学报
2008年 第2期

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