摘要
介绍了以柠檬酸为起始原料合成3-(二甲基叔丁基硅氧基)戊二酸酐的方法。该路线经脱羧反应、加氢还原、羟基保护、酯水解和再闭环,以总收率为30.3%得到目的产物。同时讨论了合成过程中发烟硫酸的浓度、加氢还原的催化剂、反应时间对环合收率的影响,得到合成3-(二甲基叔丁基硅氧基)戊二酸酐的的适宜条件。认为该法工艺路线简单,是适合工业生产的合成路线。
3-(tert-Butyldimethylsilyloxy)glutaric anhydride, as an important drug intermediate, is synthesized from citric acid by decarboxylation, reduction, hydroxyl protection, esterolysis, cyclization, with the total yield of 30.3%. The effects of the concentration of fuming sulfuric acid, hydrogenation catalysts, reaction time on cyclization are also investigated, and the optimum condition of this synthesis is got. The results show that this simple technique has many advantages in industry.
出处
《浙江科技学院学报》
CAS
2008年第2期107-109,共3页
Journal of Zhejiang University of Science and Technology
关键词
柠檬酸
脱羧反应
氢化
闭环
citric acid
decarbaoxylic reation
hydrogenation
cyclization