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MICA基因与器官移植及前景 被引量：2

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摘要 MICA基因(major histocompatibility complex class I chain-related gene A)是MIC基因家族的一个成员,Tom’Spie的研究小组于1994年首先报道了这种MHC-Ⅰ类相关基因家族。MIC是位于MHC-Ⅲ类基因区长度为的2MB的免疫功能相关基因,包括MICA、MICB、MICC、MICD、MICE、MICF和MICG,其中MICA及MICB为功能基因,其余为假基因。MIC基因与经典MHC-I类基因具有较高的同源性,其分子结构与经典MHC-Ⅰ类分子有30%的同源性,但功能不同。国外大量临床实验及研究表明,在兼顾经典HLA配型的同时,如果MICA基因亦匹配,器官移植后受体生存率将明显提高。
作者 贺梁 董光龙
机构地区 第四军医大学西京医院胃肠外科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2008年第8期843-845,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金资助项目(3203022)
关键词 MICA MHC HLA-Ⅰ
分类号 R392.11 [医药卫生—免疫学]
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参考文献20

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同被引文献39

  • 1吕铁明,谭建明.转化生长因子β1基因型与移植肾慢性排斥反应的关系[J].中国医药生物技术,2007,2(1):28-31. 被引量：2
  • 2李川江,于立新,徐健,付绍杰,邓文锋,杜传福,王亦斌.转化生长因子β1基因多态性与慢性移植肾肾病的关系[J].南方医科大学学报,2007,27(4):535-537. 被引量：3
  • 3周惠忠,黎磊石.肾移植排异反应的机理与诊断.国际泌尿系统杂志,1987,2:15-17.
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  • 5Ro H, Hwang YH, Kim H, et al. Association of polymorphisms of interleukin-8, CXCR1, CXCR2, and selectin with allograft outcomes in kidney transplantation. Transplantation, 2011, 91: 57-64.
  • 6Rosso FC, De Sandes TV, Sampaio EL, et al. Clinical impact of polymorphisms of transport proteins and enzymes involved in the metabolism of immunosuppressive drugs. Transplant Proc, 2009, 41: 1441-1455.
  • 7Grenda R, Prokurat S, Ciechanowicz A, et al. Evaluation of the genetic background of standard-immtmosuppressant-related toxicity in a cohort of 200 paediatricrenal allograft recipients: a retrospective study. Ann Transplant, 2009, 14: 18-24.
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  • 10Roy JN, Bamma A, Poirier C, et al. CYP3A4, CYP3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics inrenal transplant recipients. Pharmacogenet Genomics, 2006, 16: 659-665.

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细胞与分子免疫学杂志
2008年 第8期

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