直肠癌镶嵌血管表达及临床意义

Expression of Mosaic Vessel in Human Rectal Carcinoma and Its Clinical Significance

目的:研究直肠癌中镶嵌血管(MV)的表达及临床意义。方法:收集本科室2004年1月至2005年1月间,50例手术切除并经病理确诊的直肠癌标本。经CD34和CEA双标免疫组织化学染色观察癌组织中的MV表达,并与淋巴转移、远处转移、生存时间等临床指标行相关性分析。结果:在50例直肠癌患者中发现20/50(40.0%)存在MV表达。Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期中MV表达的比例分别为1/12(8.3%),1/10(10%),8/15(53.3%),10/13(76.9%)。直肠癌MV表达与淋巴结转移(r=0.441,P=0.001)和远处转移(r=0.423,P=0.002)正相关、与生存时间负相关(r=-0.510,P=0.001)。结论:直肠癌存在MV表达。检测直肠癌中MV的表达对于判断直肠癌的恶性转化、病理过程,预后具有一定的临床意义。

Objective： To study the expression of Mosaic vessel（MV） in human rectal carcinoma and the clinical significance thereof.Methods： Fifty specimens of rectal carcinoma obtained from operation were stained both of CD34 and CEA to observe the expression of MV.The correlation of pathological examination and live time was analyzed.Results： ①MV was found in 20 of the 50（40.0%） specimens.The expression of MV was 1/12（8.3%）,1/10（10%）,8/15（53.3%） and 10/13（76.9%） in stage Ⅰ,Ⅱ,Ⅲ and Ⅳ.②MV was associated with existence of lymph node metastasis（r=0.441,P=0.001）,distant metastasis（r=0.423,P=0.002） positively and survival time（r=-0.510, P=0.001） negatively.Conclusion： In the sample of human rectal carcinoma,the expressions of MV have been seen in all stages.②The observation of MV in the rectal carcinoma may help to decide the prognostics and the clinical stage.