自身免疫性甲状腺疾病患者血浆丙二醛与炎症因子的检测及临床意义

Malondialdehyde and inflammatory factors testing for patients with autoimmune thyroid diseases

对初诊为自身免疫性甲状腺疾病甲状腺功能亢进症（甲亢）33例、亚临床甲亢21例、甲状腺功能减退症（甲减）25例、亚临床甲减23例、甲状腺功能正常15例，正常对照30例，进行血浆丙二醛（MDA）、超氧化物歧化酶（SOD）和炎症因子检测。甲状腺功能异常各组MDA水平显著高于正常对照组（P〈0．01或P〈0．05），SOD／MDA比值显著低于正常对照组（P〈0．01或P〈0．05）；超敏C反应蛋白、肿瘤坏死因子足MDA重要影响因素。

One hundred and seventeen patients with newly diagnosed autoimmune thyroid diseases （AITDs） and 30 normal controls （NCs） were selected. All the patients were divided into 5 groups： hyperthyroidism group （ n = 33 ）, subclinical hyperthyroidism group （ n = 21 ）, hypothyroidism group （ n = 25 ）, subclinical hypothyroidism group （ n = 23 ） and euthyroidism group （ n = 15 ）. Plasma malondialdehyde （ MDA）, superoxide （SOD） and inflammatory factors levels were measured. Our results showed that plasma MDA level in dysthyroidism groups was significantly higher than that in NCs group （ P 〈 0. 05 or P 〈 0. 01 ）. SOD/MDA ratio in AITD groups was significantly lower than that in NCs group （ P 〈 0. 05 or P 〈 0. 01 ）. In a multiple step-wise regression analysis, serum highly sensitive C-reactive protein （hs-CRP）and tumor necrosis factor-α （TNF-α）were independent factors of MDA. This study might suggest that plasma MDA level in AITD patients receiving no treatment may increase. MDA may be correlated with hs-CRP or TNF-α levels.